A 1980 Python should be a wonderful Python...but that being said...every Python should be taken on its own merits. After forty years it could be worn...it could be out of time...it could be absolutely perfect in all respects. As a rule...there's nothing to worry about with any era Python...until it's been inspected.
Posted on another thread was a reminder of the Colt strike from 1986-1990. I would likely be more skeptical of pythons made in that time frame. Pre-strike pythons likely fine but evaluate each on its own merits. Good luck!
Pulled the trigger on a nineties model!!! Will see how she is. I made the best informed decision I could, and will live with the results like a big-boy. Life is too short to not shoot a Python. My brother bought a vintage RX-Z at 23, and I bought a Python for the same price as that car. Call me crazy but this is my dream gun!
Again, you have to judge the gun on it's own merits.
All you can really say is that overall Colt quality of the 1990's wasn't up the standards of the quality of the 1950's, which was better then the 1960's, which was better then the 1970's...etc.