First, have a look at this thread where the question about a new Python was asked years ago and ALL the internet experts weighed in and said absolutely not, Colt will never make another new Python again. https://www.coltforum.com/forums/python/103252-colt-going-reintroduce-python-revolver.html
Now it should be agreed that Colt will 99% never make a new Python like how it did the old one (i.e., hand made). It would be CNC made and everyone here is saying it won't be as good as the old, hand-made ones were. This is not necessarily true.
Consider an older Python to be like a Browning B25. Both were made by hand to exacting tolerances and are excellent firearms that are highly desirable. The B25 is still made that way. Is it the best there is? Browning says so Tullio Fabbri would disagree. His guns are considered the absolute best shotguns on earth and are almost completely machine made (apart from assembly). He has a $10 million CNC machine just to make screws. Korth went from making its revolvers like old Pythons and B25s (all hand made) to making them like Fabbris. They are different from the older models but still highly desirable.
If Colt can use very high quality materials and mfg these guns to exacting tolerances, there is no reason to believe that a new Python would not be a desirable gun in its own right. If it could make the new Python to be the equal or better of a new Korth National Standard, I would love to have some.