My 2 most favorite loads to shoot in my python are: 7 grains of unique and a 158 grain SWC. Also 13 grains of 2400 and same bullet.These are loaded in Starline 357 brass with Winchester primer. I have never noticed these loads showing any signs of being excessive. Should I have any reservations about using these in my colt. I keep my guns nice, but generally am a shooter and so shoot them.I probably have been reading on the internet too much.