It depends on whether it's a Colt factory commemorative or one made by someone like "America Remembers".
The non-Colt "America Remembers" or "American Historical" guns are never worth the original issue price and seldom appreciate in value.
Colt factory jobs are always more valuable then non-Colt, and most center fire Colt commemoratives are always worth more than a standard production gun simply because they are factory done.
The Scout .22's are usually worth little or no more then a production Scout because Colt made so many of them and they usually weren't as nicely done as center fire models.
However, fire ONE shot through a factory commemorative or lose ANY of the papers, box, tag, or anything else that shipped with it and the value goes down.
How much depends on the actual commemorative. Some are very valuable and even fired or missing items can still be valuable.
So, if a Colt factory commemorative is fired or missing items, depending on the actual model, it can be considered a shooter.
A non-Colt factory job is never worth the sell price and if used or missing items it's pretty much just a shooter.