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I've had very good results with a 250g Laser Cast bullet over 9.0g of Unique for my 45 Colt Anaconda. I've had good groups using 6.2g of Titegroup for my SAA.
I had great goups with a 260g Speer HP over 6.5 grains of HP-38 for the Anaconda, though I'm sure it wasn't going over 750 fps.
 
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