You will be just fine with +ps. I shoot .357s in mine and save the .38 specials for my .38 specials. Be aware that a steady diet of .38 specials will leave powder residue about .135" back from where the .357 will, and might impede easy loading of .357s if you don't clean it out real good. It isn't a problem, really, unless you're in some kind of hurry (read: need to reload right now!), and are out of .38 specials all of a sudden-like in an extreme 'social' situation. Heck. Overspeculation on my part, eh?.What are the chances, anyway?