I've shot both for almost a lifetime and they feed the same. In my experience, the 44-40 is more accurate and just as easy to load. I jumped through many hoops and could never get my 45 rifles (Rossi-1:24 twist) to come close to the groups below.
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1860 Uberti 44-40 with no wind. 1:20 twist, Accurate 43-230E bullet over 34.5 gr. OE III BP.
I turned the elev. down and shot a 3 shot, 1.5" group in his tail. I will say that the 44-40 does not shoot that good.
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The pig was shot with a 44-40 Uberti 66 rifle. Again, 1:20 twist. I lowered the elevation, probably 1 MOA for the second group. Notice it was quite abit more powder. That lot of BP was weak.
I have a new 1860 Uberti Iron frame that I just got in and am playing with. Yesterday I shot a 5 shot grp. at 50 yards with it that measured .888" with the Accurate 43-252K cast bullet and H4198 So, I'll admit, I am partial to the 44-40.
Billy