Just off the range and fired both dedicated 45 ACP revolvers with Blazer Brass 230g Plated TMJ round nose and Federal Syn-tech 205g Hollow Points. Fired brass simply falls out of the chambers. Both guns handle both loads equally well, with the 1858 Remington adjustable sight bottomed out, it hits high, so some adjustment needed. The 1860 Colt hits a touch high when I can see all of the horse head in and above the hammer notch. These are 5-7 yard engagements on steel, so, really, both can simply be point shot ignoring the rear sights. But the Colt is nice, it sights like a shotgun.
The Colt 1860:
Pros: Smaller, lighter, slimmer, better pointing, better recoil control and less hand slap, gated cylinder, simple endshake control bushing, racier looking, many grip options, trigger guard never busts the knuckle. Cylinder safety detent.
Cons: Sights not amenable to fine target work, No coil mainspring since I'm not equipped to drill and mill MIM hammers, More parts to keep track of when disassembled. Possibly shoot loose sooner.
The Remington 1858:
Pros: Fixed barrel/top strap, coil main spring, fewer grip options, doesn't bust knuckle as bad as an unrelieved factory grip loop, adjustable front sight, 5 firing pins, cylinder safety detent.
Cons: Longer, wider, heavier, have to pocket/table/holster receiver to load and unload the cylinder, cylinder fiddly to reinstall, cylinder safety detents harder to find/visualize, still wraps the knuckle (not bad with the chosen mods/loads though....short of shooting it all day, I doubt I'd mind at all.)
Having fired both side by side for a few dozen rounds, my initial thought is to give the "I like it best" nod to the Colt 1860, though, its close. In the end, even though the 1858 is more feature rich, the 1860 is smaller, lighter, easier to shoot and easier to manipulate (load/unload/Safety and sight).
But, will see....I don't know which will go in the holster in Sept for deer season.....that'll take more shooting.